Omega 3 (DHA/EPA) have natural anti-inflammatory activity because they inhibit the conversion of arachidonic acid to the pro-inflammatory: prostaglandin E2, thromboxane A2 and leukotriene B4, as well as the pro-inflammatory cytokines, tumor necrosis factor alpha (TNF-a) and interleukin 1 alpha.
TNF-a is released by stimulated mast cells. Cells involved in inflammation have receptors for TNF-a and are activated to synthesize more TNF-a, this amplifies the inflammation response.
Omega 3 significantly inhibits the lipoxygenase (LOX-5 pathway) which is responsible for the conversion of arachidonic acid to inflammatory leukotrienes in neutrophils and monocytes. This also supresses phopholipase C-mediated signal transduction which is also involved in inflammatory conditions.
Omega 3 also significantly inhibit the conversion of pro-inflammatory arachidonic acid to the enzyme cyclo-oxygenase COX-2.
In addition to salmon, sardines and mackerel; walnuts and flaxseed also have high levels of omega 3. Hodgson Mill milled flaxseed provides 2600 mg of omega 3 oils per two tablespoons. Hodgson Mill is available in many foodstores in the baking section. Milled flaxseed can be added to oatmeal, cold cereal etc. Enjoy a tablespoon of milled flaxseed throughout the week to help bock inflammatory mediators.
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