Thromboxane A2 is a potent inflammatory compound produced by cells in response to injury. Thromboxane A2 causes blood vessels to constrict and the blood to clot (platelet aggregation). Down regulating thromboxane A2 helps block inflammatory responses and helps regulate blood pressure which reduces damage to the vascular endothelium: the inner protective lining of the artery.
EPA omega 3 inhibits the synthesis of thromboxane A2 from arachidonic acid in platelets (small blood cells). Arachidonic acid is a fatty acid from which series 2 and 4 inflammatory mediators such as leukotrienes, thromboxanes, and prostaglandins are generated.
Of additional benefit: fish oils enhance the synthesis of prostacyclin, a prostaglandin that produces vasodilation and makes platelets less sticky. Therefore, platelets will not cluster and narrow the coronary arteries and blood vessels will not squeeze/constrict allowing blood to flow more freely to the cells & tissues of the heart. Unobstructed blood flow and dilated coronary arteries reduce the work load of the heart.
Source:
Importance of n-3 fatty acids in health and disease
William E Connor
American Journal of Clinical Nutrition, Vol. 71, No. 1, 171S-175S, January 2000
Comments